Thrombin is a critical link in thrombosis1-4

  • Thrombin is at the center of a dynamic process that leads to a thrombus early on, but continues with further activation of platelets and inflammatory pathways.1-3
  • Thrombin is the most potent physiologic platelet agonist known4

Adapted from Croce K et al. Curr Opin Hematol. 2007;14:55- 61.
ADP=adenosine diphosphate.

Thrombin in clot progression

The clot contains activated platelets and active thrombin, which continues to activate and recruit more platelets and propogate local inflammation through leukocyte and endothelial cell activation, fueling thrombosis5,6

Adapted from Mann KG et al. Arterioscler Thromb Vasc Biol. 2003;23:17-25.

Safety Considerations
ANGIOMAX with provisional use of glycoprotein IIb/IIIa inhibitor is indicated for use as an anticoagulant in patients undergoing percutaneous coronary intervention (PCI), and in patients with or at risk for heparin-induced thrombocytopenia and thrombosis syndrome (HIT/HITTS) undergoing PCI. ANGIOMAX is intended for use with aspirin and has been studied only in patients receiving concomitant aspirin. ANGIOMAX is contraindicated in patients with active major bleeding or hypersensitivity to ANGIOMAX or its components. The most common (≥10%) adverse events for ANGIOMAX were back pain, pain, nausea, headache, and hypotension. An unexplained fall in blood pressure or hematocrit, or any unexplained symptom, should lead to serious consideration of a hemorrhagic event and cessation of ANGIOMAX administration. Please see complete prescribing information.

1Croce K, Libby P. Intertwining of thrombosis and inflammation in artherosclerosis. Curr Opin Hematol. 2007;14:55-61.

2Coughlin SR. Thrombin signalling and protease-activated receptors. Nature. 2000;407:258-264.

3Mann KG. Thrombin Formation. Chest. 2003;124:4S-10S.

4Monroe DM, Hoffman M, Roberts HR. Platelets and thrombin generation. Arterioscler Thromb Vasc Biol. 2002;22:1381-1389.

5Mann KG, Butenas S, Brummel K. The dynamics of thrombin formation. Arterioscler Thromb Vasc Biol. 2003;23:17-25.

6Brummel KE, Paradis SG, Butenas S, Mann KG. Thrombin functions during tissue factor-induced blood coagulation. Blood. 2002;100:148-152.